While Federer and Nadal will look to reignite the flair and fight they showed to reach last year's final, 2018 could have a different script at play.
Images from Day 3 of the US Open, at Flushing Meadows, New York.
Former world number one Andy Murray won his first ATP tour singles match in nearly nine months with a 6-3, 6-7(6), 6-1 victory over American Tennys Sandgren in the opening round of the Zhuhai Championships.
Second seed Daniil Medvedev will launch his bid to win his first major title against veteran Frenchman Richard Gasquet.
World number one Roger Federer underlined his dominant position in the game by securing his sixth ATP title of the year with an impressive 6-0, 7-6 win over Novak Djokovic in the Cincinnati Open final on Sunday.
Roger Federer has now won all the seven finals he has contested in Cincinnati. Rediff.com takes a look at a few other events that have ensured prolific returns for the Swiss master.
Novak Djokovic's outstanding serving, mighty forehand and all-court defence delivered him a ninth straight win over Stefanos Tsitsipas in their Red Group match.
Djokovic withdraws from Western & Southern Open, to 'turn focus on US Open.'
The fifth seds were beaten by the unseeded Argentine pair of Gaston Etlis and Martin Rodriguez in the ATP Masters.\n
Mahesh Bhupathi and Max Mirnyi stunned top seeds Lukasz Kubot and Oliver Marach in straight sets to storm into the doubles final of the Valencia Open.
The Indian pair went down to Mark Knowles of Bahamas and Daniel Nestor of Canada at the ATP Tennis Masters in Cincinnati.
A doubles title continued to elude Mahesh Bhupathi and Max Mirnyi as they lost the Valencia Open final to British brothers Andy and Jamie Murray in Valencia.
Raducanu stormed into the third round of the Cincinnati Open
The 14-time Grand Slam winner said he is happy and proud to have reached the summit of the game for a fourth separate spell.
American teenage sensation Coco Gauff became the youngest player to win a WTA title in 15 years as she beat former French Open champion Jelena Ostapenko in the Linz Open final on Sunday.
The top seeds will take on seventh seeds Wayne Arthurs and Paul Hanley of Australia.
Simona Halep ended Beatriz Haddad Maia's dream run in Toronto
Murray, 28, moved up above Federer to second in the ATP's latest rankings on Monday, courtesy of his dazzling displays in Montreal culminating in 6-4, 4-6, 6-3 victory over Serb Djokovic in an absorbing three-hour duel.
Novak Djokovic cruised past Germany's Jan-Lennard Struff 6-3, 6-1 on Wednesday to reach a record-equalling eighth Western & Southern Open semi-final in New York where he will face Spaniard Roberto Bautista Agut.
Top seed Novak Djokovic made quick work of Tennys Sandgren at the Western and Southern Open on Tuesday, never dropping serve en route to a 6-2, 6-4 win over the American, while big-serving Milos Raonic enjoyed a straight sets win over Andy Murray.
Roger Federer says he does not regret passing up the chance to topple great rival Rafael Nadal from the top of the world rankings at the ATP Finals in London this week.
Novak Djokovic's already brilliant season took on another dimension on Sunday when the world number one became the first man to win six Masters titles in a calendar year by dismissing Andy Murray 6-2, 6-4 in Paris.
Roger Federer and Andy Murray advanced to the semi-finals of the Western & Southern Open in contrasting fashion on Friday to set up a rematch of their Wimbledon clash.
A summary of sports events and sports persons, who made news on Friday.
The winners of the season's first three grand slams Novak Djokovic, Andy Murray and Rafa Nadal put on a masterclass at the Western and Southern Open on Wednesday, strolling into the third round with straight sets wins.
World number one Novak Djokovic and number two Andy Murray crashed out of the Western and Southern Open within an hour of each other on Friday, before Rafa Nadal restored order with a win over old rival Roger Federer.
Summary of sports events and persons who made news on Monday
Federer has been brandishing an aggressive style of play, forcing the action and rushing in to half-volley weak second serves to forge an advantage.
'Goran had quite a big influence on me to change my mentality and focus on my game. He changed my serve, I started to get aggressive and that is what I needed in my career'
Frenchman Benoit lost his temper in the third game of the second set when top seed Tsitsipas halted the match to attend to a broken shoe lace.
The Serb's dominance in 2016, says Bikash Mohapatra/Rediff.com, is way beyond numbers. It's about how he forced his opponents into submission.
Summary of sports events and persons who made news on Sunday
Images from Day 1 of the 2022 US Open at the USTA Billie Jean King National Tennis Center, in Flushing Meadows, New York, on Monday.
With three of the four Grand Slam titles and a record six Masters Series crowns scooped up in a year of domination, Novak Djokovic could be forgiven for using the ATP Tour Finals in London as a well-earned lap of honour.
A ruthless Sorana Cirstea took full advantage of Karolina Pliskova's patchy form at the China Open on Thursday, reaching the quarter-finals as she consigned the recently dethroned world number one to a 6-1, 7-5 defeat.
Summary of sports events and persons who made news on Wednesday
Swiss teenager Belinda Bencic capped a brilliant run to the Rogers Cup title on Sunday.
Second seed Angelique Kerber stayed on track in her quest to unseat Serena Williams as world number one by beating Mirjana Lucic-Baroni of Croatia 6-2, 7-6(7) on Wednesday to reach the third round of the US Open.